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While NSAIDs undermine healing by damaging the gut lining and impairing tissue repair, opioids affect pain through a completely different pathway by suppressing pain perception within the central nervous system rather than addressing inflammation or injury
While GLP1 medications are designed to act on appetite and satiety, they dont address all of the systems involved in weight regulation
Reference: Drucker DJ (2018)
Metabolic research in obese animal models, for instance, sometimes benefits from the corticotrophic co-activation as an additional readout
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